Recent studies demonstrated the percentage of PD-L1-stained tumor cells was highly comparable among 22C3, 28–8 and SP263 PD-L1 assays, while SP142 assay exhibited fewer stained tumor cells, [8, 9] which was in accordance with the proportion of PD-L1 level population in KEYNOTE-407 (higher PD-L1 high patients) and IMpower131 (higher PD-L1 negative patients). This evidence concerns the gene CD274 and neoplasm.