Medical eligibility criteria included patients with CD4 count less than 350 cells/ml and/or the patient is symptomatic with HIV infection in WHO clinical stages III and IV and patient presents with severe hepatic liver function tests > 5 times the upper limit of normal, or end-stage renal disease; a patient having an acute opportunistic infection is not eligible to initiate ART. The gene discussed is CD4; the disease is stage 5 chronic kidney disease.