HDAC2 and osteosarcoma: Interestingly, an increase in sarcospheres (Fig. 5e and Additional file 8) and colonies formation rates (Fig. 5f and Additional file 8) was also detectable for HDAC2 depleted-MG63 and Saos2 cells and compared to mock cells, which further supports the idea that HDAC2 Knockdown was effective in promoting stemness of osteosarcoma cells (Fig. 5 and Additional file 8).