HMBS and amyotrophic lateral sclerosis: According to the predominant type of aggregated protein found, ALS is classified as ALS-TDP, ALS-FUS, or ALS-SOD; and FTLD as FTLD-Tau, FTLD-TDP, FTLD-FUS, or FTLD-UPS (for Ubiquitin-Proteasome system) [102].