Neutrophils are the primary source of vascular endothelial growth factor [39], while neutrophils-derived proteinases degrade cytokines and chemokines [40, 41] and remodel the extracellular matrix [42], favoring tumor proliferation, local invasion, angiogenesis and tumor vascularization, promoting metastatic potential [39–43]. This evidence concerns the gene VEGFA and neoplasm.