However, in line with our results, Buergy et al. (using the ELISA method) showed that MMP-1 and MMP-9 expressions significantly increase in aggressive FTC or advanced clinical PTC (with extrathyroid invasion, lymph-node metastasis, and high degree of tumor infiltration) compared to adenomas [18]. The gene discussed is MMP9; the disease is thyroid cancer, nonmedullary, 2.