In accordance to our results, Huang et al. evaluated mRNA and protein levels of HMGB1, MMP-9 and VEGF-C in 58 PTC, 20 adenomas, 25 MNG and 10 normal participants, using the IHC method; they found that protein levels of MMP-9, VEGF-C, and HUMGB1 were increased in PTC patients. The gene discussed is HMGB1; the disease is adenoma.