Hence, the aim of the present study was to investigate possible influences of the PLIN4 (rs8887), APOB (rs5742904), ADIPOQ (rs1501299), HSD11β1 (rs848910 and rs12086634), and APOE (rs7412 and rs429358; alleles ε2, ε3, and ε4) genes on lipid and glucose levels, abdominal circumference, and obesity in a sample of children and adolescents from a population in southern Brazil. This evidence concerns the gene PLIN4 and obesity due to melanocortin 4 receptor deficiency.