Eltrombopag (ELT) is an orally bioavailable small molecule, Thrombopoietin Receptor (TPO-R) agonist, approved for the treatment of idiopathic thrombocytopenia (ITP) and thrombocytopenia associated with chronic HCV in both pediatric and adult patients [14, 15]. The gene discussed is MPL; the disease is Thrombocytopenia.