In addition to promoting angiogenesis, SOX4 induced ET-1 may also promote tumor-progression in an autocrine manner by inducing EMT or for example by affecting T-cell infiltration, both of which have demonstrated in ovarian cancer (Buckanovich et al., 2008; Rosanò et al., 2005; Rosanò et al., 2013). The gene discussed is EDN1; the disease is ovarian carcinoma.