EDN1 and neoplasm: Our SOX4-regulated RNAseq data in HMLEs showed enrichment for one of these vascular signatures (Figure 7—figure supplement 2C) suggesting that SOX4 may drive tumor angiogenesis in Claudinlow tumors by regulating these genes in addition to EDN1. This may contribute to the poor survival of patients with the SOX4 signature in patients with Claudinlow tumors.