Moreover, SOX4 has been shown to control the TGF-β-induced epithelial-to-mesenchymal transition (EMT), a process associated with increases in tumor-initiating cells, in invasive and migratory capacity, in metastasis and in drug resistance (Zhang et al., 2012; Tiwari et al., 2013; Kalluri, 2009; Vervoort et al., 2013b; Lourenço and Coffer, 2017). The gene discussed is SOX4; the disease is neoplasm.