It is the first describedmember of Ras GTPase-activating protein (RasGAP)family that encodes a p120-RasGAP protein (16, 19).The involvement of Ras-related signaling pathways in thedevelopment of embryonic heart has been emphasized bythe significant contribution of the components of thesepathways in the pathogenesis of RASopathy disorders(17, 20-22). This evidence concerns the gene RASA1 and RASopathy.