RASA1 and coronary artery disorder: In this study, we used whole exomesequencing (WES) as a powerful method for detectingthe genetic aetiology of a heterogeneous disease suchas CHD (1, 13), and found a germline ‘homozygous’missense mutation c.1583A>G p.(Tyr528Cys) in thepleckstrin homology (PH) domain of RASA1 (Fig .2) ina consanguineous Iranian family.