For the first time, our results showed that cytochalasin Hcould successfully increase the expression of PCDH10 inthe U87MG cells which is in agreement with Hirano andTakeichi (19); Nagase et al. (20); Wolverton and Lalande(21) and Andreasen et al. (22) reported that PCDH10gene plays a tumor suppressor role in most tumors andhigh expression of PCDH10 in the tumor cells in vitrosignificantly inhibited the proliferation and re-invasion oftumor cells to the adjacent tissues. This evidence concerns the gene PCDH10 and neoplasm.