Overall, comparison of PCOS cases with controls showed downregulation of extracellular matrixprotein 1 (ECM1); catenin (cadherin-associated protein), alpha 1 (CTNNA1); integrin, alpha 5 (ITGA5); laminin, alpha3 (LAMA3); laminin, beta 1 (LAMB1); fibronectin 1 (FN1); and integrin, alpha 7 (ITGA7). The gene discussed is LAMA3; the disease is polycystic ovary syndrome.