To explore the effects of the circ_0078767/miR‐330‐3p/RASSF1A axis on NSCLC in vivo, we established the following five A549 cell groups: NC group, circ_0078767 group, si‐circ_0078767 group, cotransfected si‐circ_0078767 and miR‐330‐3p inhibitor group and cotransfected si‐circ_0078767 and RASSF1A group. Here, RASSF1 is linked to non-small cell lung carcinoma.