Even though more and more biomarker and target of glioma emerged in recent years, such as IDH1, P53, MGMT, EGFR, nevertheless, none could reveal the general view of nosogenesis, as for its heterogenicity and complexity.52, 53, 54, 55 Taken together, our study illuminated the regulatory mechanism of hsa_circ_0076248 in glioma oncogenesis via the mediation of SIRT1 expression by sponging miR‐181a and suggested that hsa_circ_0076248 and miR‐181a as well as SIRT1 as potential therapeutic targets for future glioma therapy. The gene discussed is MGMT; the disease is glioma.