EGFR and carcinoma of esophagus: For example, the activation of JAK‐STAT via IL6 could promote oesophageal cancer cell survival in paracrine manner.7 EGFR signalling could also trans‐activate JAK‐STAT and promote oesophageal cancer cell migration.8 Besides, the ligands activation and cross‐talk with other signalling, little is known about the potential mechanisms and insights into novel components of JAK‐STAT signalling in dealing with oesophageal cancer progression.