Rheumatoid arthritis is a progressive autoimmune disease with multifaceted pathobiology involving numerous cells, including monocytes, and various signalling pathways, to drive the inflammation.28 KLF2, a transcriptional factor, is important in regulating endothelial cell development, homeostasis and activation,29 and inhibiting proinflammatory activation of monocytes.11, 14 Therefore, delineating the regulatory role of KLF2 is very important in understanding the diverse roles of KLF2 in RA pathogenesis. The gene discussed is KLF2; the disease is autoimmune disease.