The similarly high expression of the pan‐M/M marker Iba1 and CD163 in the very distinct entities of pilocytic astrocytomas of WHO grade I and IDH1R132H‐non‐mutant GBMs, as also shown by others 31, challenges a general M1/M2 concept of M/M polarization in gliomas. Here, AIF1 is linked to central nervous system cancer.