In PDOX models, GAM levels were not related to an invasive or noninvasive growth pattern (data not shown). Interestingly, high levels of GAMs in the GBM IZ or NAB did not correlate with overall survival neither in PDOX models (Figure 4D–F) nor in the large cohort of IDH1R132H‐non‐mutant GBM patients (assessed by Iba1‐, CD68‐, CD163‐, CD206‐IHC, Figure S4B–E). This evidence concerns the gene CD68 and glioblastoma.