All these results consistent with the research that LOXL2 maintains the mesenchymal phenotype of carcinoma cells via a novel mechanism that involves the transcriptional downregulation of LLGL2 and disorganization of cell polarity and tight junction complexes28 This result may further explain the interaction between LOXL2 and SNAIL in the progress of VM. Here, LLGL2 is linked to carcinoma.