Our previous research has showed that tumour cells that form VM networks secrete matrix metalloproteinases and VE‐cadherin and laminin, which induce ECM remodelling and promote VM formation.6, 14, 37, 38, 39, 40 In this study, we found that LOXL2‐c overexpression was positively correlated with SNAIL and VE‐cadherin expression and VM and negatively correlated with LLGL2 expression in HCC tumour tissues, HCC cell lines and the xenograft model. Here, LLGL2 is linked to neoplasm.