VE‐cadherin is one of the first molecules that was identified as a VM promoter, and it is critical in VM.14, 35, 42, 43 Together, these results indicate that LOXL2 collaborated with SNAIL, further promoted the expression of the VM marker VE‐cadherin, and increased VM in HCC. The gene discussed is CDH5; the disease is hepatocellular carcinoma.