Recently, the research revealed that the collaboration of LOXL2 with SNAIL and LLGL2 influences EMT and cell polarity respectively.20, 22, 23, 24 To gain insight into the mechanism by which LOXL2 promotes VM, we studied the expression of LOXL2‐associated factors and the relationships among them in HCC tissue samples, HCC cell lines and the xenograft model. The gene discussed is LOXL2; the disease is hepatocellular carcinoma.