In conclusion, we have shown, for the first time, that there are positive correlations among LOXL2‐c and SNAIL expression and VM in HCC; moreover, our present results indicate that LOXL2 may upregulate the expression of SNAIL and VE‐cadherin, and promote VM, ultimately facilitating tumour metastasis and indicating a poor prognosis in HCC patients. Here, LOXL2 is linked to hepatocellular carcinoma.