CD274 and neoplasm: It includes the receptor–ligand system targeting programmed death-1 (PD-1), which is a cell surface receptor that blocks antitumor T-cell activity [6] after binding with programmed death-ligand 1 (PD-L1), which is expressed in 25–65% of gastric cancers and associated with tumor size, lymph node metastasis, and a shorter median survival [7–9].