CD4 and neoplasm: Accordingly, HSPs such as HSP70 which are upregulated during hyperthermia serve as key players in linking innate and adaptive immunity through the upregulation of MHC class I molecules on tumor cells, activation of pro-inflammatory cytokines and adhesion molecules facilitating immune cell trafficking into the tumor tissue, activation of NK cells, and enhanced presentation of antigenic HSP-peptide complexes to CD4+ and CD8+ T-cells by dendritic cells [42, 43].