In multivariable analysis using a Cox regression model, we found that sPD-L1 was a negative independent prognostic factor [Hazard Ratio (HR) for DFS 2.58 (1.14–5.84), P = 0.023; HR for OS 1.77 (1.01–3.12), P = 0.048] in accordance with a recent study [14], while sPD-1 was a favorable independent prognostic factor [HR for DFS 0.32 (0.14–0.74), P = 0.007; HR for OS: 0.54 (0.30–0.98), P = 0.044] in HCC. The gene discussed is HOXD13; the disease is hepatocellular carcinoma.