However, it has been reported that CD74 canalso be combined with other proteins, such as CXCR2 in signal transduction of MIF.In addition, it is suggested that blocking the signal transduction of MIF can beused as a therapeutic target in inflammatory diseases, such as atherosclerosis.Considering the multiple receptors of MIF, we believe that a combination of blockingeach receptor may achieve better therapeutic effects. This evidence concerns the gene CXCR2 and atherosclerosis.