GSN and cancer: Rearrangements of actin filaments are of great importance for both normal cell migration and cancer cell migration/invasion, and indeed, several actin-regulating proteins are implicated in cancer cell migration (reviewed by Olson and Sahai 2009), two of which are now known to bind CCT: the p21-activating kinase PAK4 (Zhao et al. 2017) and gelsolin (Brackley and Grantham 2011).