Joachimiak et al. (2014) applied a structural approach, combined with biochemical analyses, to assess the binding of human immunodeficiency virus (HIV) protein 6 to the apical domain of CCT3 and a peptide from the Box 1 region of the von Hippel-Lindau (VHL) tumor-suppressor protein to the apical domain of CCT1. Here, VHL is linked to neoplasm.