Duplication of the LMNB1 gene, which causes increased expression of lamin B1, is associated with autosomal dominant leukodystrophy (ADLD), a rare adult-onset disease characterized by progressive myelin loss in the central nervous system (Burke and Stewart, 2013; Padiath et al., 2006; Zuela et al., 2012). The gene discussed is LMNB1; the disease is adult-onset autosomal dominant demyelinating leukodystrophy.