The frequencies of STAT4 rs7574865 G allele were 71 of 102 (69.6%), 50 of 60 (83.3%), and 61 of 80 (76.3%), while the frequencies of STAT4 rs7574865 T allele were 31 of 102 (30.4%), 10 of 60 (16.7%), and 19 of 80 (23.8%) in ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls, respectively Table 2. This evidence concerns the gene STAT4 and rheumatoid arthritis.