When compared in pairs in terms of STAT4 rs7574865 genotype, homozygote mutant and wild-type genotypes were solely significantly different between ACPA-positive RA patients and ACPA-negative RA patients (P=0.041), where ACPA-positivity was not necessarily associated with TT genotype (OR 10.06, 95% CI:0.5-189, P=0.123) albeit weakly correlated (τ=0.278, P=0.045) Table 2. The gene discussed is STAT4; the disease is rheumatoid arthritis.