The frequencies of STAT4 rs7574865 GG genotype (wild-type) were 26 of 51 (51%), 20 of 30 (66.7%), and 25 of 40 (62.5%), the frequencies of STAT4 rs7574865 GT genotype (heterozygote mutant) were 19 of 51 (37.3%), 10 of 30 (33.3%), and 11 of 40 (27.5%), and the frequencies of STAT4 rs7574865 TT genotype (homozygote mutant) were 6 of 51 (11.8%), 0 of 30 (0%), and 4 of 40 (10%) in ACPA-positive RA patients, ACPA-negative RA patients, and healthy controls, respectively Table 2. The gene discussed is PRTN3; the disease is rheumatoid arthritis.