A study revealed that when the E. coli NTR (nitroimidazole reductase) gene was introduced into colorectal and pancreatic cancer cell lines by retroviral delivery, it was observed that NTR-expressing clones of both cell lines were more susceptible to cytotoxic effects mediated by the prodrug CB1954 [30], which revealed that NTR and CB1954 [5-[aziridin-1-yl]-2, 4-dinitrobenzamide] can be used as an attractive combination for treatment of tumors that employs VDEPT technique. Here, NTSR1 is linked to familial pancreatic carcinoma.