Additionally, AL exerted anti-gastric ulcer effect in the rat model through decreasing inflammatory mediators (i.e. tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-6), and prostaglandin E2 (PGE2) and increasing epidermal growth factor (EGF) and trefoil factor2 (TFF2) [9]. The gene discussed is CXCL8; the disease is gastric ulcer.