CD49a expression by CD103+CD4+ and CD103+CD8+ TILs may allude to this, as CD49a expressing CD103+CD8+ TILs were the most potent killers of tumor cells in a mouse model of melanoma and CD49a defines cytotoxic CD8+ TRM in skin (16, 66, 67). The gene discussed is CD8A; the disease is melanoma.