SETBP1 and osteomyelitis: Previous studies had indicated that specific virulence genes may play a pivotal role in toxin-mediated diseases, such as enterotoxins B and C (encoded by seb, sec) in toxic shock syndrome, enterotoxin A, B, and Q (encoded by sea, seb, and seq) in food poisoning, and Panton–Valentine leukocidin (PVL, encoded by lukS-PV and lukF-PV genes) in difficult-to-treat osteomyelitis and severe SSTIs (Karauzum et al., 2012; Spaulding et al., 2013; Hu et al., 2017; Jiang et al., 2017; Nakaminami et al., 2017).