ABL1 and Parkinson disease: Accordingly, systemic administration of c-Abl inhibitors (e.g., imatinib and nilotinib) may hold promise for protection against the degeneration of nigral dopaminergic cells in PD and further antiparkinsonian effects (Hebron et al., 2013a,b; Karuppagounder et al., 2014; Wu et al., 2016; Zhou et al., 2017; Abushouk et al., 2018).