TLR2 and Stroke: In the condition of oxidative stress, as well as in aging, hyperlipidemia, atherosclerosis, and stroke, Toll-like receptor-2/3/4/6 (TLR-2/3/4/6) are up-regulated or activated (Salminen et al., 2008; Nagyoszi et al., 2010; Zhang et al., 2012).