Genetic defects in the three SH3 and multiple ankyrin repeat domains (SHANK) genes (SHANK1, SHANK2, and SHANK3) are associated with multiple major neuropsychiatric disorders, including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BPD; Guilmatre et al., 2014; Bourgeron, 2015; de la Torre-Ubieta et al., 2016). Here, SHANK3 is linked to bipolar disorder.