Fromer et al. (2014) reported a de novo SHANK1 frameshift mutation in a SCZ patient. Lennertz et al. (2012) found that the T allele of the SHANK1 promotor variant rs3810280 leads to impaired auditory working memory capacity as assessed with digit span in SCZ patients and subjects clinically at risk for developing a psychosis but not in healthy controls. The gene discussed is SHANK1; the disease is psychotic disorder.