TNF and obesity due to melanocortin 4 receptor deficiency: We found a significant main association of ‘obesity status’ with mRNA levels of adiponectin (F1,102 = 6.890, P = 0.010), leptin (F1,102 = 6.062, P = 0.015), IL-1β (F1,102 = 14.327, P < 0.001), IL-6 (F1,102 = 7.191, P = 0.009), TNFα (F1,102 = 4.271, P = 0.041), PLAUR (F1,102 = 8.848, P = 0.004), CCL2 (F1,102 = 10.667, P = 0.001) and CSF3 (F1,102 = 16.403, P < 0.001).