Pairwise comparisons indicated that obese patients diagnosed with anxiety disorders (ANX subgroup) had significantly lower adiponectin mRNA levels (P < 0.05) than in non-obese patients without mental disorders (non-MD subgroup), whereas obese patients with mood disorders (MOOD subgroup) had lower mRNA levels of IL-1β (P < 0.05) and adiponectin (P < 0.01). This evidence concerns the gene ADIPOQ and mental disorder.