MYCN and neoplasm: Interestingly, the ESC miRNA signature score in double transgenic mice tumors (MYCN/ALKF1174L) is significantly higher than in ALKF1174L-driven tumors (significant difference with p = 1.905E-2), in concordance with shorter time to tumor appearance and thus more tumor aggressiveness in double transgenic mice compared to ALKF1174L-transgenic mice (Fig. 1H).