EIF2AK3 and lung carcinoma: Moreover, IRE1α was known to be a substrate for HRD1-dependent ERAD in synovial fibroblasts and this regulation was conserved in lung cancer cells, and the PERK, but not ATF6α protein was identified in HRD1 complex (Figs. 3, 4 and Supplementary Fig. 7f)48.