The correlation between c-Kit expression and mitochondrial metabolism in bone marrow neutrophils (Fig. 1e, g, h) and 4T1 elicited neutrophils (Fig. 4a, b), together with the production of Kit ligand (SCF)33 (supplemental Fig. 6a) and absence of c-Kit expression in 4T1 tumour cells (Supplemental Fig. 6b), suggested the c-Kit:SCF axis might be involved in maintaining mitochondrial metabolism in neutrophils. This evidence concerns the gene KIT and neoplasm.