As expected, downregulation of TAP1 in IGR-Heu-TAP tumour cells resulted in an increase in their susceptibility to anti-ppCT16–25 CTL-mediated lysis, while it resulted in a decrease in anti-ppCT9–17, anti-ppCT50–59, anti-ppCT91–100 and CTL-mediated killing (Supplementary Figure 4a). The gene discussed is TAP1; the disease is neoplasm.