CD44 and neoplasm: In radioresistant CSCs during tumour regrowth, aldehyde dehydrogenase+, CD44+, CD133+, and epithelial adhesion molecule+ lesion areas increased by 11%, 19%, 24%, and 4% respectively, in irradiated vs. control tumours, which showed no significant difference compared to irradiated EC-p53KO tumours (Supplementary Fig. 7a, b).