To study the potential relationship between tumour vasculature and radioresistance, we used EC-specific Trp53-knockdown (EC-p53KD) and -knockout (EC-p53KO) mice (Tie2-Cre;Trp53flox/+ and Tie2-Cre;Trp53flox/flox, respectively). The gene discussed is TP53; the disease is neoplasm.