CXCL12 and neoplasm: Following coculture with WT tumour ECs, most CD206+SDF-1+F4/80+ cells were elongated (like M2 macrophages) when differentiated with cytokines interleukin-4 (IL-4) and IL-10 from M-CSF-treated BMDMs, whereas after coculture with EC-p53KO tumour ECs, iNOS+SDF-1+F4/80+ cells were flattened (like M1 macrophages) when differentiated with lipopolysaccharides (LPS) plus interferon-γ (IFN- γ) from M-CSF-treated BMDMs (Fig. 6g).