Slit/Robo signalling has been shown to interact with the Wnt/β-catenin signalling in different types of tumour cells1,13, and we found here that Robo1/2 KO pancreatic cells exhibit a reduced level of Axin2 expression but Lef1 appeared unchanged at E12.5 (Fig. 7a). Here, LEF1 is linked to neoplasm.