In addition, our experimental data revealed a down-regulation of Eftud2 and Gnai3 in the head of E11.5 embryos (following 2 days of antenatal ATRA treatment), and these genes are involved in Mandibulofacial dysostosis, Guion-Almeida type (MIM: # 610536) and Auriculocondylar syndrome (MIM: # 602483) respectively. The gene discussed is GNAI3; the disease is auriculocondylar syndrome.