In order to further investigate the activities and potential for development of rocaglates as TRAIL sensitizers, ROC and 55 natural and synthetic analogs were assessed for their ability to sensitize the well-characterized TRAIL-resistant ACHN RCC cell line to TRAIL-induced apoptosis in parallel with analysis of their protein synthesis inhibitory activity in the same cells under the same conditions. Here, TNFSF10 is linked to renal cell carcinoma.