MAPK3 and breast carcinoma: In addition, a Golgi-localized GAP for cdc42 regulated the Arp2/3 complex and F-actin dynamics by controlling cdc42 activity49, and endogenous cdc42 was able to inhibit intrinsic migration or invasion and alter PKCd, Erk1/2, and PKA phosphorylation in some aggressive breast cancer cells30.