In our cell model, LIF/LIFR-rich cancer cells (cLIF) expressed lower levels of phosphorylated YAP1 as well as total YAP1 protein (Fig. 6a, b), leading to the hypothesis that LIF regulates LIFR–YAP1 signaling to promote NPC invasive phenotypes. This evidence concerns the gene YAP1 and nasopharyngeal carcinoma.