We demonstrated that p-YAP1 (S127) was markedly downregulated in LIF-rich cells (cLIF) and siRNA knockdown of LIFR in cLIF cells enhanced YAP1(S127) phosphorylation, implying that intracellular LIFR signaling acts as an upstream regulator of YAP1 and LIFR functions as an oncogene promoting NPC progression. The gene discussed is LIFR; the disease is nasopharyngeal carcinoma.