ABCG8 and cholestasis: We observed five significant associations: the Pro290Ser missense variant in SLC10A2 associates with an increased risk of acute pancreatitis (see below), the previously reported8 Asp19His missense variant in ABCG8 also associates with increased risk of acute pancreatitis and cholecystitis, and the two rare coding variants we reported in ABCB4 (Leu445GlyfsTer22/rs756082276[CCT] andGly622Glu/rs756935975[T]) both associate with high risk of cholestasis of pregnancy, as previously reported7 (Supplementary Data 2).