MALAT1 and hepatocellular carcinoma: For another example, metastasis associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to interact with serine/arginine (SR) proteins (Tripathi et al., 2010), modulate mRNA alternative splicing (Tripathi et al., 2010), and over-express in non-small-cell lung cancer (Ji et al., 2003), hepatocellular carcinomas (Lin et al., 2007) and breast cancer (Guffanti et al., 2009).