SETDB1 and hepatocellular carcinoma: In HCC, SETDB1 is thought to be the epigenetic regulator that is upregulated most markedly, playing a key role in the proliferation and metastasis of HCC cells.19, 20 In the present study, it was found that SETDB1 was a direct target gene of miR-621, which could reverse the miR-621-induced radiosensitivity.