The mRNA and protein expressions of SETDB1 in HCC tissues were significantly lower compared with the para-carcinoma normal tissues (p < 0.001; Figures 4A and 4B), and the expression of SETDB1 in HCC cells was also lower compared with the normal liver cells (p < 0.001; Figure 4C). Here, SETDB1 is linked to hepatocellular carcinoma.