Nearly 30–40% and 15–20% of patients with type 1 and type 2 diabetes on insulin therapy, respectively, suffer from severe hypoglycemia with an incidence of 1.0–1.7 episodes per patient per year [2], [3], [4], because the physiological counterregulatory response to hypoglycemia is impaired in diabetes. The gene discussed is INS; the disease is diabetes mellitus.