HDAC4 and Parkinson disease: PD GBA-N370S patient-derived dopamine neurons are known to exhibit impaired cellular calcium homeostasis (Schöndorf et al., 2014), and low synaptic calcium levels in hippocampal and cerebellar granule cell cultures triggered the shuttling of HDAC4 from dendritic spines to the nucleus (Bolger and Yao, 2005, Chawla et al., 2003).