DNAJB1 and Huntington disease: However, the modulation of other chaperones, such as Hsp40, which cooperates with Hsp70 to mediate mHtt disaggregation (Scior et al., 2018), and chaperonins like CCT, which may intervene when Hsp70 folding activity fails and prevent mHtt aggregation (Kim et al., 2013; Tam et al., 2006), arise as potential therapeutic strategies in HD.