The absence of significant detrimental or beneficial effects of Lcn2 on these AD-like characteristics is notable, taking into account the strong neurodegenerative [22, 25, 27–29, 31–34, 65–69] and neuroprotective [35–37] effects that were reported for Lcn2 in various in vitro and animal models of brain injury and disease. The gene discussed is LCN2; the disease is Alzheimer disease.